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Darifenacin has a 12 fold higher selectivity for M3 compared to M1 & M5, 59-fold greater selectivity for M3 vs M2 & M4 (rxlist.com)

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Along these lines, an emerging theory linking excitotoxicity and mitochondrial dysfunction suggests that an accumulation of lactate, a metabolic byproduct which is toxic (especially to nerve cells) at high concentrations may play a role in ALS progression (Vadakkadath Meethal 2012)

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Free mtDNA, ROS, and the MAVS pathway are required for the recruitment of NLRP3 to mitochondrial membranes