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Unlike earlier GLP-1 drugs, semaglutide's molecular structure made it stable enough for oral formulation, expanding treatment options beyond injection-only therapy

The Inflation Reduction Act (IRA) allows for government price negotiations on branded drugs

Although semaglutide can be very beneficial in treating diabetes, it can also have some side effects

Mutations in the SLC19A3 gene that encodes THTR-2 causes biotin-thiamin-responsive basal ganglia disease, which is treated with high-dose co-supplementation with biotin and thiamin for life (see Biotin-thiamin-responsive basal ganglia disease below)

Conversely, conditions which cause drooling or sialorrhoea (excessive salivation) can cause angular cheilitis by creating a constant wet environment in the corners of the mouth

doi: 10.1002/JLB.MR0618-213R 245 SchieberM.ChandelN