India is home to over 100 million people with diabetes and approximately 250 million classified as obese or overweight.[15] What makes the situation uniquely dangerous is the Thin-Fat Indian paradox: South Asians tend to accumulate more visceral (belly) fat, liver fat, and less lean muscle mass at lower body weights than Western populations.[8][9][10] While GLP-1 medications are a global phenomenon, they are particularly critical for the Thin-Fat Indian phenotype
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Both fasting and post-prandial GLP-1 levels are lower in people with obesity as compared with those in normal-weight subjects, as obesity is characterized by a blunted post-prandial GLP-1 increase [11]
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Ding, D., Wang, M., Wu, J
