deplete glutathione Iron accumulation, depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events NSAIDs Depletes Glutathione | Essential

Folate is a co-factor for enzymes that regulate DNA synthesis and methylation, and is more directly involved in these processes than B12---making it vital for proper gene expression as well as cell growth, repair, and division, especially during periods of rapid growth like pregnancy

Dicho de forma sencilla, si la mancha es un exceso de pigmento en un punto, el glutatin acta en una de las vas principales que regulan cmo se fabrica ese pigmento

Michele M

Severe deficiency in folate can cause megaloblastic anemia, which causes fatigue, weakness, and shortness of breath

It also highlights significant knowledge gaps, indicating the need for future research to elucidate curcumins mechanism of action, safety, efficacy, and therapeutic potential for treating various human and animal diseases

Important note: it remains investigational and lacks FDA approval for human use