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(54) demonstrated that increased expression of ATF6 was associated with elevated apoptosis, ER, and mitochondrial disorder in pancreatic tissues from SAP patients and humanized serine protease 1 (PRSS1) transgenic mice

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This protein resides in the cytoplasm and the nucleus, where it interacts with the PAS/LOV photoreceptor protein (PLP) to mediate light-dependent control of ascorbate synthesis

The method employs immunoaffinity purification using a polyclonal GHRH antibody followed by nano-ultrahigh performance liquid chromatography-high resolution/high accuracy tandem mass spectrometry (LC-HRMS/MS)