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This Polyol (Sorbitol) pathway is activated only if the concentration of glucose in cells is high because the enzyme Aldose reductase has a relatively low affinity for glucose (and conversely high Michaelis Menten constant K m )

Dose, timing, and duration get written out for you, not left as a vague "take as needed." The amounts are set per person from your labs and your goal, then adjusted at reassessment

doi: 10.3390/ph16121699

they have not measured long-term outcomes

Alternative pre- and post-harvest technologies are needed in this case to reduce the amount of contamination in commercial foods or, at the very least, guarantee that AF levels are below safe limits (Atakan & Caner 2021)