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L.SchneiterG.ChofflonM.FunakoshiH.NakamuraT.et al (2010)

Begin by reducing ongoing exposure, reviewing medications and alcohol, confirming liver and kidney safety, restoring adequate protein and nutrients, supporting bowel elimination and treating confirmed methylation, gut or biliary abnormalities

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The duration should be determined by your prescribing physician based on your specific goals, response to treatment, and overall health picture