The World Health Organization on Monday released new guidance on GLP-1 medications for adults with obesity, recommending their long-term, continuous use when clinically appropriate
Its shares fell nearly 50 percent in 2025 and are down a further 15 percent this year, while the company now expects sales and profit to decline 5 percent13 percent in 2026, mainly because of US pricing pressure and loss of semaglutide exclusivity in markets such as Canada and China, according to CNBC
Additionally, many medications commonly prescribed for these conditions (such as certain antidepressants, antihypertensives, and finasteride) can affect sexual function
Appeal denials
However, others may need a little longer to adjust
Other alternatives to Contrave or Wegovy include: Ozempic (semaglutide): once-weekly injection approved for people with type 2 diabetes, sometimes used off-label for weight loss Rybelsus (semaglutide): oral semaglutide tablet taken once daily Victoza ( liraglutide ): daily diabetes injection, available in a lower-cost generic version Metformin : generic diabetes medication that has shown modest amounts of weight loss in clinical studies , though it isnt approved for weight management
