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Pentose phosphate pathway (PPP) activation Increased glycolytic flux diverts glucose-6-phosphate into the PPP, which generates NADPH

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Subsequently, the modified -catenin forms a complex with the TCF/LEF transcription factor to activate transcription

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NAION: sudden vision loss signal now recognised by EU regulators The thread mentions NAION, a rare optic nerve event that can cause sudden, often irreversible vision loss