The compound has substantial cosmetic-ingredient regulated use in topical preparations under the relevant cosmetic regulatory frameworks, distinct from any pharmaceutical approval
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Paracetamol, particularly in combination with weak opioids, is more likely than NSAIDs to cause rebound headache (medication overuse headache), although less of a risk than ergotamine or triptans used for migraines.[26] Paracetamol is contained in many preparations (both over-the-counter and prescription-only medications)
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