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Critically, Trx dysfunction blocks cystine reduction, creating a vicious cycle of cystine accumulation-NADPH depletion-Trx inactivation

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[DOI] [PMC free article] [PubMed] [Google Scholar] [141].Jardim BV, Moschetta MG, Leonel C, Gelaleti GB, Regiani VR, Ferreira LC, Lopes JR, Zuccari DA, Glutathione and glutathione peroxidase expression in breast cancer: an immunohistochemical and molecular study

Vitamin C provides antioxidant protection