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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls

Ethics statement The study was approved by the Medical Ethical Committee of the San Gallicano Dermatological Institute and it was conducted according to the Declaration of Helsinki principles

This makes the toxin water-soluble, allowing the body to flush it out through urine or bile

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