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12,13 Related studies have added that DAC can up-regulate the expression of PD-L1 in metastatic colorectal cancer, which may make PD-1/PD-L1 inhibitors more likely to play a role, that is, the combination of DAC and anti-PD-1/anti-PD-L1 antibodies may be a potential treatment for radiosensitization of osteosarcoma