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PMID: 15380576

doi: 10.1038/319230a0 147 YardenYWeinbergRA

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PMID: 25 FilesJKSarkarSFramTRBoppanaSSterrettSQinKet al

While previous findings did not exclude that oligomers can form intracellularly before they are released 53,54,55 , based on the efficacy of the A-anticalin in APP23xPS45 mice, it is unlikely that such released oligomers reach sufficiently high concentrations to cause neuronal dysfunction in vivo

However, intrathecal delivery of morphine results in transient cerebrospinal fluid concentrations of approximately 25 M [134], which might result in significant antioxidant effects and covalent reactions despite the brief tissue exposure