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METHOD DETAILS Constructs The human GLP-1R was modified to replace the native signal peptide with that of haemagglutinin (HA) to improve receptor expression and contain N-terminal Flag tag epitope and C-terminal 8xHis tag

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This explains why manufacturers specify strict storage guidelinesthey're designed to maintain chemical stability and ensure the medication delivers its full therapeutic effect

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Size-exclusion chromatography coupled with multi-angle laser light scattering was applied to analyze the aggregation properties of semaglutide, among others [90]