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When the GST is absent, the likelihood of the toxin-GSH conjugation is diminished

This matters even more during harsh Indian summers when heat stress and dehydration further drain your micronutrients

Moreover, skatole, a tryptophan-derived metabolite typically low in healthy individuals, was also elevated, suggesting disruption of gut homeostasis (Fournier et al., 2023)

Nature 604 , 697707 (2022)

Brigelius, R., Muckel, C., Akerboom, T.P

Kidney Dis (Basel) 6:395406 Adema AY, de Roij van Zuijdewijn CLM, Hoenderop JG, de Borst MH, Ter Wee PM, Heijboer AC, Vervloet MG, NIGRAM consortium (2018) Influence of exogenous growth hormone administration on circulating concentrations of -klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study