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Importantly, oxidative damage caused by the production of ROS has been linked to the etiology of different types of human cancer [23, 36]

In particular, heart mitochondria from mice with selective TSPO deletion in hearts undergo MPT and are as sensitive to ischemiareperfusion injury as hearts from control mice

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The CTH gene is located on chromosome 1p31.1 and is composed of 13 exons that undergo alternative splicing generating three mRNAs, each of which encode distinct protein isoforms