At picomolar to nanomolar concentrations, GHK-Cu stimulated the synthesis of collagen in skin fibroblasts, increased accumulation of total proteins, glycosaminoglycans (in a biphasic curve) and DNA in the dermal wounds in rats
MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Hypoglycemia (binds insulin receptor at higher doses) Theoretical organ enlargement with chronic high-dose Theoretical concerns in active malignancy (IGF-1 axis) Known interactions Insulin / sulfonylureas (hypoglycemia risk) Concurrent rhGH not standard Contraindications Active malignancy (IGF-1 axis growth signaling) Pregnancy/lactation (unstudied) Diabetic retinopathy (theoretical exacerbation) REGULATORY STATUS FDA Not FDA-approved
Rather than relying solely on calorie restriction and exercise plans, healthcare providers now have access to medications that target some of the biological mechanisms involved in hunger, appetite regulation, blood sugar control, and weight gain
PTSD + MDD ( n = 18) and PTSD only ( n = 7) participants did not differ in circulating levels of MMP-9 ( p = 0.282), TIMP-1 ( p = 0.394), nor TIMP-2 ( p = 0.784)
Maybe its not the GLP-1 thats doing something, but rather the patients who receive GLP-1 drugs may differ from other patients in ways that affect cancer outcomes, including weight, diabetes control, access to care, screening, other medications, and overall health
Disease eradication using PZQ monotherapy is severely limited by the low activity of this drug against juvenile worms
