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For example, persistent gastrointestinal symptoms leading to dehydration or a noticeable drop in eGFR or increase in UACR should prompt a temporary pause in medication

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In particular, we deeply appreciate the efforts of the Japan Diabetes Society's Committee on the Safe Use of Anti-Diabetes Medications

Rushing the dose increases can backfire, causing nausea that leads some patients to stop treatment prematurely

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It also seems to have a positive effect on the reduction of cognitive impairment