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Overall, the favorable metabolic profile induced by GLP-1 RAs (weight loss and reduced caloric intake, improvement in glycemic compensation) allows one to hypothesize their potential effectiveness in the treatment of NAFLD, in addition to T2DM and obesity

The application of mechanical loading through physical therapy exercises can stimulate mechanotransduction pathways in fibroblasts, leading to the upregulation of collagen synthesis and the strengthening of the repaired ligament

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Importantly, our findings do not suggest that GLP-1RAs should be considered a viable alternative to definitive treatment for higher-risk aneurysms, and our study design strictly investigated patients who did not receive treatment in real-world clinical practice