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Community sources and trial data describe these effects at 0.5 mg: Dry mouth (most common), insomnia (more common with afternoon or evening dosing, per community sources), elevated heart rate (5-10 bpm), constipation, mild mood elevation

Enzyme activities can be expressed as normalized per cell, per mg protein or per g DNA

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Persistent bleeding over multiple bowel movements, bleeding that increases in volume rather than resolving, or new-onset bleeding in patients aged 45 or older should trigger urgent medical assessment