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86 DRAM1 participates in the regulation of autophagy and apoptosis in intestinal epithelial cells by positively regulating JNK, and knockdown of DRAM1 can lead to a decrease in the phosphorylation levels of c-Jun and JNK, inhibit the formation of autophagosomes, and alleviate the symptoms of UC

Iarc Monogr Eval Carcinog Risks To Humans 61:1241 Javaheri A, Kruse T, Moonens K, Mejas-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Kniger V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

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127 USP1 inhibitors, such as ML323 and SJB-043, protect against -cell apoptosis and hyperglycemia under diabetic conditions