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Stress paradigms studied in humans include hypoglycemia during the insulin tolerance test (Figure 4), and venipuncture (187)

With advancing age, GH production declines, a phenomenon paralleled by physical and functional alterations similar to those observed in AGHD

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Cytotoxicity profiling in vitro shows a dose-dependent pattern: cell viability holds within research-relevant concentration ranges but declines meaningfully above approximately 1 mM in culture, a threshold well outside the concentration windows described as biologically productive in the wound healing and gene expression literature

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