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When primary vessels are compromised, the peptide can recruit backup vascular networks that normally remain dormant

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Inhibitors of secretory phospholipase A2 (sPLA2), which generates LPA (unspecified species) precursors, have shown preclinical activity

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Interestingly, transplant of the small intestinal microbiome from animals fed regular chow restores both central insulin and intestinal nutrient-sensing signaling mechanisms, highlighting the role of the gut microbiota in shaping bile acid pool composition 272,273

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