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Certain studies have found that when nerves are exposed to mercury, the myelin sheath (the fatty substance that surrounds the axon of some nerve cells and helps with electrical signaling) can become severely damaged, interfering with how nerves communicate

PLoS One 3:e1944, PMID: 18398470 Berk M, Johansson S, Wray NR, Williams L, Olsson C, Haavik J, Bjerkeset O (2011) Glutamate cysteine ligase (GCL) and self reported depression: an association study from the HUNT

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Alcohol affects the quality and duration of our sleep

J Endocrinol Investig 19:433440 Muoz MT, Barrios V, Pozo J, Argente J (1996) Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications

The nerve damage of vitamin B12 deficiency may be related to this