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Insulin in the form of basal-bolus injection therapy may be used as first-line therapy [Grade A, Level 1 (129) for insulin] Rapid-acting analogue insulin aspart, lispro or glulisine may be used over regular insulin for postprandial glucose control, although perinatal outcomes are similar [Grade B, Level 2 (356,357) for aspart and lispro

Quality assessment Quality assessment was based on the following criteria concealment of treatment allocation

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The area ratio of these peaks to the ISTD were used to estimate their concentrations

Results vary, but many patients experience significant, sustained weight loss over time when combined with a structured plan