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A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

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74 This may partly explain the ability of GLP-1RAs to reduce MACE incidence, which has been demonstrated in research

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The 2.4-milligram dose was also effective, helping participants lose an average of 15.6% of their weight