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GLP-1RAs, approved for type 2 diabetes (T2DM), enhance incretin signaling to improve postprandial glucose metabolism
MIN6 cells were pretreated with 1 mM metformin for 2 h (thin dotted line of left panel) or simultaneously with 10 nM GLP-1 (thick dotted line of left panel)
Int J Biochem Cell Biol Jan;43(1):47-59
Its primary research focus has been on localised tissue repair
Subsequently, secondary bile acids, key signaling molecules produced by bile acids and gut microbiota metabolism, are bound to membrane receptors (Takeda G protein-coupled receptor 5, TGR5/G protein-coupled bile acid receptor 1, GPBAR1) and nuclear receptors (Farnesoid X Receptor, FXR), which stimulates colonic secretion of GLP-1 and PYY