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In standard functional assays, orforglipron shows greater than 100-fold selectivity for the GLP-1 receptor over the glucagon receptor, the GIP receptor, and the secretin receptor

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ALCs ability to freely pass the brainblood barrier could help brain fatty acid transport for oxidation in mitochondria that improves brain energy metabolism

Timeline: Week 1-2 post-GLP-1 : Ghrelin rebounds, food noise returns most noticeably Week 3-6 : Body is recalibrating

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