insurance claims data representing nearly a million adults treated with tirzepatide or semaglutide between 2018 and 2025
Other rare but serious side effects include: Seizures Signs include sudden convulsions or loss of awareness
After injection, the medication reaches steady-state concentrations in approximately 4 to 5 weeks, with a half-life of about one week
These occur because GLP-1 receptors in the gut and brain are being activated, slowing digestion and sometimes causing gut hypersensitivity
Inflammatory cytokines can enhance tissue factor expression, initiating the coagulation cascade and increasing thrombin generation, leading to higher clotting potential
Therefore, this drug class offers benefits for obesity in patients with type 2 diabetes, a common comorbidity