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IL-33 has been shown to stimulate melanin biosynthesis in NHEM by promoting phosphorylation of p38 MAPK and CREB, leading to increased expression of TYR, TRP-1, and DCT through MITF, ultimately resulting in increased melanin production (Zhou et al., 2014)

Average daily intake of -tocopherol from food (including enriched and fortified sources) for adults (20 years of age) in the US is 11.5 mg for men and 9.5 mg for women (27)

Weight may stabilize if nutrition and exercise are well managed

Three (3) year shelf life

Statistical analysis Statistical analyses were performed by one-way ANOVA followed by Bonferronis post-test for multiple comparisons, as appropriate