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That reference is a nod to the marvel superhero, Wolverine, who was known to have the supernatural ability to heal from most wounds and injury

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Shiraz E-Medical Journal, 15 (4)

Research suggests that similar to -MSH, MT-1 primarily targets melanocortin 1 receptors (MC1R) on melanocytes, potentially supporting melanin synthesis and pigmentation, thus reducing UV-induced damage to the stratum corneum

In addition to the HLA gene, the PTPN22 gene has emerged as a crucial player in RA pathogenesis, primarily influencing T-cell activation and serving as a genetic marker for predicting the RA risk [29]

In addition to the abovementioned limitation, the lack of clinical data beyond preclinical trials limits their potential application in clinical settings