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Older individuals produce by a lot less glutathione, which creates increased oxidative stress and cellular damage

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Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

Furthermore, the disrupted basement membrane serves as a direct migratory pathway for inflammatory cell infiltration, thereby exacerbating the inflammatory response within the brain parenchyma (156)

More recently, glutathione-based chemical peel has also gained popularity.[] GLUTATHIONE AS A MESOTHERAPY Though there is lack of literature regarding the efficacy and methodology of use of glutathione as mesotherapy solution, it is widely being practiced by the dermatologists for treatment of melasma either as monotherapy or along with ascorbic acid, pyruvic acid, vitamin E, etc.[] TRANSDERMAL DELIVERY To enhance the permeability and reduce the foul odor associated with the topical applications of glutathione, Lee et al