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Stimulated by TNF- and IL-1, RANKL secreted by synovial fibroblasts induces macrophages to transform into osteoclasts ( Another major reason for fibroblast-induced disease in synovial tissue is that these cells are resistant to apoptosis ( Synovial hyperplasia induced by metabolic conversion may originate from signaling

Section 425.658 is amended in paragraph (d) by removing the phrase HEBA and adding in its place the phrase population adjustment

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These were repeated at the end of the study with regular safety visits

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