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(5.2) Rare cases of serious regurgitant cardiac valvular disease have been reported

2.2.1 Carotegrast methyl Carotegrast methyl (AJM300) is an oral small-molecule 4-integrin antagonist tested in this multicenter, double-blind, placebo-controlled Phase III RCT (NCT03531892) involving 203 patients with moderately active UC who received either 960mg three times daily or placebo for 8 weeks (46)

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