The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (McConnell et al., 2015) (Figure 1)
1a, Supplementary Fig
Herbal medicines: report suspected adverse reactions to the Yellow Card Scheme
Preclinical models converge on immuneinflammatory signaling, HPA axis dysregulation and neurotransmitter alterations as recurrent mechanistic pathways (Ravi et al., 2021
Owing to the presence of bromodomain, the TRIM family members (TRIM24, TRIM28, and TRIM33) can act as chromatin remodelers
With respect to drugs, primaquine causes hemolysis regularly, but aspirin does so only sometimes