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As rates for obesity and cardiovascular disease increase, so too does the demand for GLP-1 drugs

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doi: 10.1172/JCI119060 61 TsengC-CZhangX-YWolfeMM

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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked