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Moreover, the long-term effects of therapeutic GIP receptor antagonism in humans are not fully elucidated and are thought to depend on the specific drug molecule, receptor functions, and the extent of GLP-1 receptor activation

This combination is thought to provide a more comprehensive simulation of natural GH rhythm by attacking the signaling process from two different receptor angles

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Drug Metab Rev 44(1):88106, doi:10.3109/03602532.2011.602688 Jirillo E, Caccavo D, Magrone T, Piccigallo E, Amati L, Lembo A, Kalis C, Gumenscheimer M (2002) The role of the liver in the response to LPS: experimental and clinical findings