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Enzymatic Reactions of S -Adenosyl- L -Methionine: Synthesis and Applications

It has been proven through the utilization of cell-based and transgenic animal models that high-risk variants are responsible for cellular damage and mortality, whereas the reference APOL1 G0 is relatively non-toxic (105, 107, 216)

Narrow margin between therapeutic dose and toxic dose

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doi: Iwakawa H, Nakamura Y, Fukui T, Fukuwatari T, Ugi S, Maegawa H, et al

It shows up clinically often as the diseases we fear most