Retatrutide, the triple agonist targeting GLP-1, GIP, and glucagon receptors, shows approximately 24% weight loss in phase 2 trials
Additionally, because tesofensine affects norepinephrine, it can raise both heart rate and blood pressure
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From a theoretical pharmacological standpoint, combining a peptide with putative lipolytic activity (AOD 9604) with a potent triple incretin receptor agonist (retatrutide) could potentially amplify metabolic effects but this is speculative and raises the possibility of compounding adverse effects with no safety data to guide dosing or monitoring
Im just not sure that in the next six to nine months were really going to know that GLP-1s are giving people an unfair advantage or are so risky that we need to ban them, Koller said