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[5] Disruption of these pathways leads to accumulation of homocysteine and methylmalonic acid, metabolic signatures linked to megaloblastic anemia and demyelinating neuropathy

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For example, vitamin C, through its antioxidant properties, can neutralize free radicals through different mechanisms including the elimination of free radicals and reactive oxygen or nitrogen species, the down-regulation of enzymes producing free radicals, and the modulation of Nuclear Factor Erythroid 2-Related Factor and Nuclear Factor Kappa B (NF-B), which are important mediators in oxidative stress (44)

In some cases, it can cause a temporary increase in blood pressure

The same group further developed paliperidone palmitate poloxamer-guar gum nanogel for schizophrenia treatment by nasal delivery directly to the brain bypassing the BBB

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