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Both GLP-1 drugs and bariatric surgery are known to improve blood sugar control, which is why semaglutide was originally approved as a treatment for type 2 diabetes

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The encapsulation of insulin or semaglutide in Bu-PEG NPs formed insulin-loaded Bu-PEG NPs (BU-NP@INS) and semaglutide-loaded Bu-PEG NPs (BU-NP@Sema), significantly enhancing the oral bioavailability and hypoglycemic function of INS and Sema [85, 86]

Their therapeutic effects span across areas such as antimicrobial activity, cells proliferation and migration, synthesis of collagen, and more