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Affinity purification and mass spectrometry analysis have shown that Erastin interacts with voltage-dependent anion channel 2 (VDAC2) (103), reducing the permeability of VDAC2 to the reduced form of nicotinamide adenine dinucleotide (NADH), altering its ion selectivity, and disrupting mitochondrial respiratory chain oxidative phosphorylation (104)

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Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition

doi: 10.1016/j.bbrc.2016.08.124 65 ZhaoJ.WangQ.LiuZ.ZhangM.LiJ.FuZ

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