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If endogenous glutaredoxin availability or activity is limiting, then rxYFP may become oxidized by other processes (e.g., by ROS from the respiratory chain) and thus lose its ability to act as a specific reporter for the glutathione redox couple

[ General Peptide Safety/Dosing Limitations: General Pharmacokinetic Concepts and Clinical Drug Development

The FC between the two groups indicated is expressed as log 2 ratio

While many specific genes are affected, the overall trend is a progressive weakening of the oocyte antioxidant defense system