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The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

10.1104/pp.107.4.1139 41 DudlerR.HertigC.RebmannG.BullJ.MauchF

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Although nearly 50 years of published research show that GHK-Cu Copper Tripeptide-1 Powder can increase skin glycosaminoglycan production, inhibit matrix metalloproteinases, and regulate mild inflammatory responses, the existing data has major compliance limitations