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Body weight and metabolism: Larger individuals or those with faster metabolism may need slightly higher doses

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Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig

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S., Royal, I., Naujokas, M