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J Biol Chem 278:2224322249

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For patients requiring further glycaemic control, the dose may be increased to a maximum of 2 mg once weekly after at least four weeks on the 1 mg dose

Dosing Framework by Clinical Context and Biomarker Status Glutathione dosing should account for baseline oxidative stress, antioxidant capacity, and individual metabolic factors

In other words, the hormonal symphony plays out of tune and out of cadence