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Arnsten's work translated into two medications now in clinical use guanfacine (Intuniv) for ADHD and prefrontal disorders, and prazosin for PTSD a reminder that targeting the chemistry of executive function is a validated therapeutic strategy, not a fringe one.5,6 The takeaway for the cognitive-longevity conversation: the executive brain ages and degrades along chemical pathways we can name

Keeping the face cool, avoiding hot showers, and sleeping on a clean pillowcase each night helps reduce inflammation

Random trial and error can cause more damage

In astrocytes lacking GLP-1R, the increase in FGF21 is associated with improved systemic glucose homeostasis and memory formation

We monitor your response, side effects, and adjust protocol as needed

The 2020 Xu et al