It is worth noting that the gut microbiota lives in virtually anaerobic conditions of the GIT, so the results received under aerobic conditions (21% oxygen) may differ and even be opposite
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Overall, anti-IL-12/23 and anti-IL-23 agents provide an effective new option for moderate-to-severe IBD in patients who fail or are intolerant to anti-TNF therapy, and future generations of anti-IL drugs targeting finer subunits or downstream signaling will further promote precision and personalized treatment
Its also worth noting that other studies have NOT found any higher risk of brain development issues at higher serum B12 levels (quite the opposite actually)
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