Abstract In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH)
1995 Jun;61(6):1263-7
Upconversion nanoparticles intercalated in large polymer micelles for tumor imaging and chemo/photothermal therapy
In Alzheimer's disease (AD), the disruption of MAMs enhances inflammatory signaling and impairs the cellular response to ER stress ( 5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation ( Importantly, this theory posits that the production of A is influenced by mitochondrial dysfunction triggered by toxins
Excessive free radicals in the body lead to oxidative stress, which is at the root of many chronic diseases, including cancer, diabetes, heart disease, Alzheimers disease, and infertility
Extensive evaluation for other potential causes was negative
